Cationic-Enhanced Spectrofluorimetric Method for Determination of Selective Serotonin Reuptake Inhibitor Duloxetine Hydrochloride in its Dosage Forms
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منابع مشابه
Cationic-Enhanced Spectrofluorimetric Method for Determination of Selective Serotonin Reuptake Inhibitor Duloxetine Hydrochloride in its Dosage Forms
Duloxetine hydrochloride is chemically, N-methyl-3napthalen-1-oxy-3-thiophen-2-yl-1-amine. Duloxetine hydrochloride (Fig. 1) is a new selective serotonin and norepinephrine reuptake inhibitor used for major depressive disorders. It is also indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy. Duloxetine hydrochloride is considered among the most import...
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A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of duloxetine hydrochloride in pure and pharmaceutical dosage form. Duloxetine hydrochloride showed strong native fluorescence in 0.05 M acetic acid having excitation at 225 nm and emission at 340 nm. Effect of different solvents were thoroughly investigated. The calibration graph was linear ...
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Duloxetine (DLX), is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) recommended for maintenance treatment of major depressive disorder, neuropathic pain especially diabetic polyneuropathy (first-line treatment), generalized anxiety disorder, stress urinary incontinence and fibromyalgia. The present investigation describes the validation of rapid, sensitive, cost effective and re...
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New simple spectrofluorimetric method with enhanced sensitivity has been developed and validated for the determination of the antidepressant paroxetine (PXT) in its dosage forms and plasma. The method was based on nucleophilic substitution reaction of PXT with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole in an alkaline medium (pH 8) to form a highly fluorescent derivative that was measured at 545 nm...
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Spectrophotometric and spectrofluorimetric methods were developed for the determination of dothiepin hydrochloride (DOP) in different dosage forms. The spectrophotometric method (Method I) is based on formation of a binary complex with eosin at 540 nm in acetate buffer of pH3.7. The absorbance-concentration plot is rectilinear over the range 1-10 μg/mL with LOD of 0.18 μg/mL and LOQ of 0.54 μg/...
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ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2013
ISSN: 0970-7077,0975-427X
DOI: 10.14233/ajchem.2013.15035